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Datamodule

SingleCellDataModule

Bases: MegatronDataModule

LightningDataModule wrapper of SingleCellDataset

Parameters:

Name Type Description Default
data_path Union[str, PosixPath]

Path to preprocessed single-cell data files

required
tokenizer Tokenizer

Maps gene names to ids and vice-versa

required
collator

Used to batch samples

required
process_item

Function defining how each item should be processed

required
num_workers int

Number of workers to use

10
num_mask_per_sample int

Number of masked versions of a single sample to be returned by each worker

required
train_batch_size int

Batch size for training

required
val_batch_size int

Batch size for validation

required

Attributes:

Name Type Description
cfg Config

Configuration object

data_path Union[str, PosixPath]

Path to preprocessed single-cell data files

median_dict dict

Dictionary containing median values

tokenizer Tokenizer

Tokenizer object

setup_called bool

Flag indicating if the setup method has been called

dataset SingleCellDataset

Single-cell dataset object

Source code in bionemo/geneformer/data/singlecell/datamodule.py
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class SingleCellDataModule(MegatronDataModule):
    """LightningDataModule wrapper of `SingleCellDataset`

    Args:
        data_path (Union[str, PosixPath]): Path to preprocessed single-cell data files
        tokenizer (Tokenizer): Maps gene names to ids and vice-versa
        collator: Used to batch samples
        process_item: Function defining how each item should be processed
        num_workers (int): Number of workers to use
        num_mask_per_sample (int): Number of masked versions of a single sample to be returned by each worker
        train_batch_size (int): Batch size for training
        val_batch_size (int): Batch size for validation

    Attributes:
        cfg (Config): Configuration object
        data_path (Union[str, PosixPath]): Path to preprocessed single-cell data files
        median_dict (dict): Dictionary containing median values
        tokenizer (Tokenizer): Tokenizer object
        setup_called (bool): Flag indicating if the setup method has been called
        dataset (SingleCellDataset): Single-cell dataset object

    """  # noqa: D415

    # Nothing says we cant pass in the dataset...
    def __init__(  # noqa: D107
        self,
        tokenizer: Tokenizer,
        median_dict: dict[str, float],
        train_dataset_path: str | Path | None = None,
        val_dataset_path: str | Path | None = None,
        test_dataset_path: str | Path | None = None,
        predict_dataset_path: str | Path | None = None,
        mask_prob: float = 0.15,
        mask_token_prob: float = 0.8,  # 80% mask token
        random_token_prob: float = 0.1,  # 10% random token, remaining 1-(mask+random) will be identity.
        seq_length: int = 2048,
        micro_batch_size: int = 4,
        global_batch_size: int = 8,
        rampup_batch_size: Optional[List[int]] = None,
        seed: int = 42,
        num_workers: int = 10,  # TODO can this be automatically set?
        persistent_workers: bool = True,
        pin_memory: bool = True,
    ) -> None:
        super().__init__()
        if predict_dataset_path is None:
            assert (
                train_dataset_path is not None and val_dataset_path is not None and test_dataset_path is not None
            ), "Provide either predict_dataset_path or (train_dataset_path, val_dataset_path, and test_dataset_path)"
        elif train_dataset_path is None:
            assert (
                val_dataset_path is None and test_dataset_path is None
            ), "Provide either predict_dataset_path or (train_dataset_path, val_dataset_path, and test_dataset_path)"
            assert (
                predict_dataset_path is not None
            ), "Provide either predict_dataset_path or (train_dataset_path, val_dataset_path, and test_dataset_path)"
        self.data_path_predict = predict_dataset_path
        self.data_path_train = train_dataset_path
        self.data_path_val = val_dataset_path
        self.data_path_test = test_dataset_path
        self.tokenizer = tokenizer
        self.median_dict = median_dict
        self.max_len = seq_length
        self.mask_prob = mask_prob
        self.mask_token_prob = mask_token_prob
        self.random_token_prob = random_token_prob
        self.seed = seed
        self.num_workers = num_workers
        self.persistent_workers = persistent_workers
        self.pin_memory = pin_memory

        rng = np.random.default_rng(seed)
        if self.data_path_train is not None:
            assert self.data_path_val is not None and self.data_path_test is not None
            self._train_dataset_ori = SingleCellDataset(
                self.data_path_train,
                self.tokenizer,
                self.median_dict,
                self.max_len,
                mask_prob=self.mask_prob,
                mask_token_prob=self.mask_token_prob,
                random_token_prob=self.random_token_prob,
                seed=random_utils.get_seed_from_rng(rng),
            )
            self._val_dataset_ori = SingleCellDataset(
                self.data_path_val,
                self.tokenizer,
                self.median_dict,
                self.max_len,
                mask_prob=self.mask_prob,
                mask_token_prob=self.mask_token_prob,
                random_token_prob=self.random_token_prob,
                seed=random_utils.get_seed_from_rng(rng),
            )
            self._test_dataset_ori = SingleCellDataset(
                self.data_path_test,
                self.tokenizer,
                self.median_dict,
                self.max_len,
                mask_prob=self.mask_prob,
                mask_token_prob=self.mask_token_prob,
                random_token_prob=self.random_token_prob,
                seed=random_utils.get_seed_from_rng(rng),
            )
            self._predict_dataset_ori = None
        else:
            assert self.data_path_predict is not None
            self._predict_dataset_ori = SingleCellDataset(
                self.data_path_predict,
                self.tokenizer,
                self.median_dict,
                self.max_len,
                mask_prob=self.mask_prob,
                mask_token_prob=self.mask_token_prob,
                random_token_prob=self.random_token_prob,
                seed=random_utils.get_seed_from_rng(rng),
            )
            self._train_dataset_ori = None
            self._val_dataset_ori = None
            self._test_dataset_ori = None

        # This is needed here, or you need to specify it in the megatron adapter thing TODO name?
        #  Note that this sampler is sequential, meaning it does not do any shuffling. Let's wrap our data in a shuffler.
        if self.data_path_predict is not None:
            n_predict = len(self._predict_dataset_ori)
            self.data_sampler = MegatronDataSampler(
                seq_len=self.max_len,
                micro_batch_size=min(micro_batch_size, n_predict),
                global_batch_size=min(global_batch_size, n_predict),
                rampup_batch_size=rampup_batch_size,
                output_log=False,  # this is needed for predict step to work
            )
        else:
            self.data_sampler = MegatronDataSampler(
                seq_len=self.max_len,
                micro_batch_size=micro_batch_size,
                global_batch_size=global_batch_size,
                rampup_batch_size=rampup_batch_size,
            )

    def setup(self, stage: str = "") -> None:  # noqa: D102
        assert getattr(self, "trainer", None) is not None, "Please only call setup after trainer is attached."

        if self._train_dataset_ori is not None:
            assert self._val_dataset_ori is not None and self._test_dataset_ori is not None
            # Trainer API
            max_train_steps = self.trainer.max_steps
            if self.trainer.max_epochs > 1:
                logging.warning(
                    "Trainer is set to run for multiple epochs. This is not recommended due to the same shuffle being used in each. Instead set max_epochs to 1 and increase the number of max_steps."
                )
            assert max_train_steps > 0, "Please specify trainer.max_steps"

            num_train_samples = int(max_train_steps * self.data_sampler.global_batch_size)
            num_val_samples = infer_num_samples(
                limit_batches=self.trainer.limit_val_batches,
                num_samples_in_dataset=len(self._val_dataset_ori),
                global_batch_size=self.data_sampler.global_batch_size,
                stage="val",
            )
            num_test_samples = infer_num_samples(
                limit_batches=self.trainer.limit_test_batches,
                num_samples_in_dataset=len(self._test_dataset_ori),
                global_batch_size=self.data_sampler.global_batch_size,
                stage="test",
            )

            # This happens exactly once during setup.
            self._train_ds = MultiEpochDatasetResampler(
                self._train_dataset_ori,
                num_samples=num_train_samples,
                shuffle=True,
                seed=self.seed,
            )
            self._validation_ds = MultiEpochDatasetResampler(
                self._val_dataset_ori,
                num_samples=num_val_samples,
                shuffle=False,
                seed=self.seed,
            )
            self._test_ds = MultiEpochDatasetResampler(
                self._test_dataset_ori,
                num_samples=num_test_samples,
                shuffle=False,
                seed=self.seed,
            )
        else:
            assert self._predict_dataset_ori is not None
            self._predict_ds = MultiEpochDatasetResampler(
                self._predict_dataset_ori,
                shuffle=False,
                seed=self.seed,
            )

    def train_dataloader(self) -> TRAIN_DATALOADERS:  # noqa: D102
        return self._create_dataloader(self._train_ds, mode="train")

    def val_dataloader(self) -> EVAL_DATALOADERS:  # noqa: D102
        return self._create_dataloader(self._validation_ds, mode="validation")

    def test_dataloader(self) -> EVAL_DATALOADERS:  # noqa: D102
        return self._create_dataloader(self._test_ds, mode="test")

    def predict_dataloader(self) -> EVAL_DATALOADERS:  # noqa: D102
        return self._create_dataloader(self._predict_ds, mode="predict", drop_last=False)

    def _create_dataloader(self, dataset, mode: Mode, **kwargs) -> WrappedDataLoader:
        """Create dataloader for train, validation, and test stages.

        Args:
            dataset: The dataset to create the dataloader for.
            mode: Stage of training, which is used to determined if consumed_samples in MegatronPretrainingSampler should be initialized to 0 (validation/test), or be set to the previous value from state_dict in case of checkpoint resumption (train).
            **kwargs: Additional arguments to pass to the dataloader.
        """
        self.update_init_global_step()
        return WrappedDataLoader(
            mode=mode,
            dataset=dataset,
            num_workers=self.num_workers,
            pin_memory=self.pin_memory,
            persistent_workers=self.persistent_workers,
            collate_fn=functools.partial(
                collate.bert_padding_collate_fn,
                padding_value=self.tokenizer.token_to_id(GeneTokenizer.pad_token),
                min_length=self.max_len,
                max_length=self.max_len,
            ),
            **kwargs,
        )